Retinal Examination by OCT to Reveal Neurodegeneration in the Brain

Recent studies suggest that amyloid beta (AB) induced Tau pathology is responsible for the severe outcome of Alzheimer’s Disease (AD) process. Data from different models support the thesis in which AB accumulation acts as a triggering event in the pathogenetic process by accelerating antecedent Tau [1]. Abnormal aggregation of tau protein ultimately leads to the formation of tangles within nerve cells. Once initiated, the tau aggregation process continues and spreads into previously healthy cells [2]. There are three main charecteristics for a taupathy: (a) an increase in tau levels; (b) a modification, like hyperphosphorylation, sometimes related to another posttranslational modifications such as truncation or acetylation; and (c) an abnormal tau aggregation [2].